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The purpose of this paper is to answer the question of how scientific excellency can be achieved. The origin of scientific excellency in Iran, national and international experiences concerning the subject has been investigated to review the literature. The authors also designed a process and then a model to test the course. Guilan University of Medical Sciences was selected as a case study for the research.

The approach used in this paper is from Future Studies, with emphasis on the “Participatory Learning and Action” method. It means that different stakeholders, including the strategic council members, managers, faculty members, students, alumni and non-academic staff, have been involved in different parts of the process.

After semantic analysis of scientific excellency in the theoretical field; the examination of national and international experiences in universities; the analysis of higher-level documents of the Ministry of Health and Medical Education as well as strategic documents of the university; the determination of the strengths and weaknesses of the Guilan University of Medical Sciences in online survey; the completion of the scientific excellency canvas in the expert panel and finally obtaining other stakeholders, a conceptual model was designed for achieving scientific excellency.

The study of the actions, policies and trends of pioneering universities indicates that it is important to consider issues such as the internationalization of education and research and the modification of university structures. To achieve a superior national and international status, the university must specifically enhance a range of different aspects, from intangible aspects, such as motivation of employees to tangible aspects, such as human resources, structure and facilities.

Scientific excellency is going to be one of main streams between universities to attract top students and researchers from all over the world. There has been little academic attempt on scientific excellency. In this research, first the authors examined the concept of scientific excellency, criteria and measurement in higher education, then based on that case study and participatory action learning method, a conceptual framework to achieve scientific excellency in Iran’s higher education system was proposed.